Runaway leaders Bayern Munich suffered only their second Bundesliga defeat of the season when they were beaten 1-0 at surprise package Hoffenheim on Tuesday.
Now sitting in 3rd place, Hoffenheim trails RB Leipzig by only one point in second as they look to secure a place in the Champions League. Bremen took a first-half lead when Zlatko Junuzovic's superb long ball was headed in by defender Theodor Gebre Selassie.
While Muller is ruled out against Hoffenheim, Bayern will be able to recall Spanish duo Javi Martinez and Xabi Alonso to the side after they served their suspensions.
Kramaric fired home in the 21st minute to seal a win which moved the hosts to within one point of second-placed RB Leipzig and extended their unbeaten run to seven games.
"We are playing good opponents every three or four days, so we want to go there and put in a good performance".
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The Bavarians almost levelled with their first real chance when Roberto Lewandowski's strike hit the crossbar. However, Bayern remained unable to overcome Hoffenheim custodian Oliver Baumann, who denied Lewandowski and Franck Ribery promising opportunities in the closing period.
Hoffenheim's next test of whether their highly touted boss has the right ingredients comes when they travel to Hamburg on Saturday, chasing a fourth consecutive Bundesliga win.
Hamburg keeper Rene Adler got the better of Aubameyang in a one-on-one early before Dortmund counterpart Roman Burki did likewise to Bobby Wood at the other end.
Naglesmann's Hoffenheim now sit third in the Bundesliga, one points ahead of Borussia Dortmund and 11 clear of fifth place Cologne.
Jojic scored his second goal in two games after picking up David Abraham's header outside the box before driving a shot past Lukas Hradecky and into the net via a post eight minutes into the second half.