Leaders Bayern Munich are racing to get key players fit in time for Saturday's big Bundesliga clash against Borussia Dortmund, with Thomas Mueller, Douglas Costa and keeper Manuel Neuer still in doubt.
Stretching its home unbeaten streak to 30 matches, Bayern outclassed their rivals all match long, dominating possession and creating chance after chance.
Dortmund's hopes of getting back in the match happen to be quashed shortly following the restart whistle as it just took four minutes for Bayern Munich to reopen the two-goal lead.
Lewandowski then made it 2-0 on 10 minutes with this slick free kick finish.
Riber and Lewandowski put the hosts ahead 10 minutes into the game, before Guerreiro pulled one back for Dortmund before the break.
It could have got better for the Bavarian club as Robben cut inside onto his favoured left foot from the right wing on two occasions but curled both efforts wide of Burki's left-hand post as the hosts completely controlled the early stages. Bayern Munich will try to rebound from Tuesday's loss to Hoffenheim, while Dortmund is coming off a resounding win over Hamburg. The top three automatically qualify for Europe's premier competition.
RB were reduced to 10 men when captain Willi Orban was sent off for a second yellow card on 88 minutes for a foul on Leverkusen's Germany forward Kevin Volland. "We're now in a top position for the last games", said Leipzig coach Ralph Hasenhuettl. His side stayed second, seven points clear of Hoffenheim.
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"That was a setback at just the right time", defender Mats Hummels said of their first ever loss to Hoffenheim.
Forward Bobby Wood crossed for Aaron Hunt to score Hamburg's victor with a quarter-hour remaining, lifting the side four points clear of the relegation zone after its fourth straight win at home.
After extending his contract to 2022, Cologne goalkeeper Timo Horn had to pick the ball out of his net in the 13th minute of the Rhine derby when Jannik Vestergaard headed the visitors in front.
Cologne slumped to a 3-2 home loss against Borussia Moenchengladbach thanks to Lars Stindl's 80th minute victor.
Piszczek joined Dortmund from Hertha Berlin in 2010.
Despite the numerical disadvantage, Leipzig claimed the victor through their Scandinavian combination as Swedish playmaker Emil Forsberg put in the cross - his 16th assist of the season - for Denmark's Poulsen.