And they hold a commanding 3-0 semi-final, first leg lead over Atletico Madrid as Los Blancos look to become the first side in 27 years to retain the Champions League. Immediately before that game, Barcelona will host fifth-placed Villarreal at Camp Nou, in a match both sides need to win.
Simeone's men must pull off a remarkable comeback in Wednesday's second leg to avoid being dumped out of the Champions League for a fourth straight season by their cross-city rivals.
"Right-back? Lucas will play at centre-back in principle and we're still debating the best option for the right-hand side: it'll be a youngster or one of the midfielders. I can only be satisfied with that".
The Colombian then powered home a header from Fabio Coentrao's cross just nine minutes later.
The former Arsenal captain took Aly Malle off for Uche Henry Agbo after 17 minutes.
Navas could do little about Atletico’s opening goal at the home side won 2-1 on the night
"We played very well with and without the ball and scoring four goals against this Villarreal side shows how well we did", said Barca coach Luis Enrique.
Vazquez then hit the bar and Casemiro somehow shot over with the goal at his mercy as Madrid's dominance of the first 45 minutes left some Granada fans in tears.
Neymar was in sensational form in his second game back from suspension and nudged Barcelona ahead in the 21st minute after pouncing on a deflected pass from Messi.
Suarez took that tally to 101 and killed the game off as a contest when he turned Jaume Costa and fired low and hard past Fernandez.
"Often it seems much more like ballet than a football move". The last time these two clubs faced off against each other in January, Barcelona needed a 90th-minute free-kick goal from Messi to tie the match at 1-1. As a result, they have to win their three remaining matches while hoping Madrid slip up between now and the end of the campaign, reports Xinhua news agency.
Salman Khan to launch Mouni Roy
Mouni Roy started her career on television with Ekta Kapoor's Kyun Ki Saas Bhi Kabhi Bahu Thi , where she played Krishnatulsi. The same report states that Salman bonded with Roy in their multiple encounters on the reality show he hosts - Bigg Boss .