The 20-year-old has become the first swimmer to win three gold medals on a single night at the World Championships. "There's no other way to say it".
After just over an hour to recover, Dressel then led the USA quartet out in a world-record rout in the 4x100 metres mixed freestyle relay.
"It was tough. My legs were burning, I really had to dig deep and get my hands on the wall first", said Manuel, 20, who actually shared Olympic gold with Canada's Penny Oleksiak previous year.
Plainwell native Mallory Comerford held her own against a field of Olympians, helping the United States claim four gold medals and shatter a world record at the 2017 FINA World Championships in Budapest, Hungary.
Caeleb Dressel, Nathan Adrian, Mallory Comerford and Simone Manuel competed in the final and took gold for the USA with a new world record, 3 minutes, 19.60 seconds. "That's the push I need, hats off to them". Mixed relays, with men and women on the same team, are a new event for the 2020 Tokyo Olympics.
Though his world championship has ended, Dressel should be far from done. The braces-wearing 20-year-old has been hailed as the natural successor to his compatriot Phelps after some breakthrough performances at this year's World Championships.
He paid tribute to the American, saying: "There are just no words to describe what he just did".
"I'm very excited about that", Dressel said.
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Quah has one final event, the 50m backstroke, on Saturday. "But more importantly, Americans went 1-2".
Phelps retired for the second time after the Rio Games.
South African Chad Le Clos is the defending champion in the event and is coming off a win in the 200m fly on Wednesday (26 July).
Sjostrom also set a new world record in the semi-finals of the 50m freestyle with a time of 23.67sec bettering the old mark of 23.73sec set by Germany's Britta Steffen in 2009.
The third gold medal of the day for U.S swimmer Caeleb Dressel - an unprecedented feat in the history of the World Championships - came in the mixed 4x100m free relay, where the North American led-off the quartet for a final winning time of 3:19.60, the second World Record of the day. Schooling's time yesterday was almost half a second slower than his Olympic record of 50.39sec, but he still remains the only Singaporean to win a medal at the World Championships.
Attributing the result to Schooling's post-Olympics hangover and six-month break, Reese told TODAY: "No matter who you are, there will be times that you get beat, but it's easier to take when you're at your fastest, and he wasn't at his fastest in this meet".
At the semi-finals on Saturday, Schooling clocked 50.78s at the Duna Arena in Budapest, Hungary to finish 4th overall. He also won bronze in the 100m fly at the 2015 edition in Russian Federation.