A red flag warning for the region is in effect through Saturday, meaning hot and dry conditions, combined with gusty winds, "will result in the potential for rapid fire spread", according to the NWS. Mandatory and voluntary evacuations have continued, with 730 homes evacuated across Burbank, Glendale, and the city of L.A., according to CBS.
Erratic winds are feeding the flames, which expanded from 1,500 acres to 3,000 as the fire raced uphill on the Verdugo Mountains overnight.
"The mayor of the City of angels, Eric Garcetti, said at a press conference Saturday that the fire said "The Tuna", which has already swallowed more than 2,000 hectares, was the largest fire in the history of Los Angeles".
Firefighters, backed by five engines, were trying to save the single home that had so far been caught by the flames in Sunland-Tijunga area, fire officials said.
The fire was first reported around 1.30 p.m. Friday and initially affected about one acre.
Cal Fire said on its website that the fire near Oroville had consumed almost 6 square miles (15 square kilometers) and was 30 percent contained.
Around 10 hours later, the LAFD said strong gusting winds meant the fire was erratic and unpredictable, leaving officials "unable to give a firm prediction on all areas potentially at risk".
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Eliminate all sources of standing water on your property, including flower pots, old vehicle tires, rain gutters and pet bowls. However, some people - less than one percent - will develop serious neurologic illness such as encephalitis or meningitis.
"Our priority is saving people and saving property", Los Angeles Fire Department Chief Ralph Terrazas told reporters. The La Tuna fire has burnt over 5,000 acres and destroyed three structures.
"Be set, have your vehicle positioned appropriately, have your pets, your documents, your pictures - all the things you want to protect - loaded up in your auto", Terrazas said.
The 210 Freeway was closed to traffic in the area after the fire jumped the road and grew to over 2,000 acres, according to the Los Angeles Times. There were no reports of injuries. However, fluctuating winds had diminished the threat to both neighborhoods, fire officials said.
People carry their belongings and dog to a vehicle as they prepare to evacuate as the La Tuna Fire approaches in the Shadow Hills neighborhood of Los Angeles, California, September 2, 2017.
As of Saturday afternoon, more than 500 firefighters were on scene, and a large portion of I-210 remained closed.
"It's snowing ash from the Burbank fire, there was a huge pop followed by my power going out", said Cory Pratt, a filmmaker, on Twitter.