Johnson will undergo surgery on his dislocated left wrist later this week and is expected to miss 2-to-3 months, Adam Schefter of ESPN reports. The Cardinals placed Johnson on injured reserve Tuesday, which means he would be out for a minimum of eight weeks and is eligible to return any time after that.
Johnson earned All-Pro honours a year ago in his first full season as a starter, rushing for 1,239 yards and 16 touchdowns in 2016 and adding 879 yards and four TDs receiving.
Before going down with the wrist injury on Sunday, Johnson rushed for 23 yards on 11 carries and had fumbled twice.
In his absence, it's expected that the Cardinals will feature a running back committee that includes former Colt Kerwynn Williams, Andre Ellington, and there's a strong likelihood that veteran running back Chris Johnson is re-signed.
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Johnson's wrist surgery has an 8-to-12 week timetable. Arians said Johnson was the final cut he made to reduce the roster to 53 players.
Johnson is in his third NFL season after being drafted out of Northern Iowa by Arizona in the third round of the 2015 NFL Draft.
Losing Johnson is a huge blow for the Cardinals, but Arians is confident his other running backs are ready to step up and pick up the slack. It's going to be extremely hard for owners without I.R. spots to keep Johnson on rosters tying up a spot for that long. Johnson against the 49ers in two games combined for 212 yards rushing and 74 receiving with four touchdowns. The Cardinals also signed running back D.J. Although ineffective running the football, Johnson was having a solid performance as a receiver with six catches for 68 yards.